This is a multicenter, cross-sectional study, including patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), aswell as a healthy control group. The objective is to recruit 300 patients with PD, 100 with MSA, 50 with PSP, and 300 healthy controls. Blood samples will be obtained from patients who provide informed consent. Plasma α-syn (t-α-syn, p-α-syn) and t-tau concentrations will be measured using IMR technology, and normal values will be established to clarify the role of relevant plasma biomarkers in the differential diagnosis of PD and their correlation with PD clinical subtypes
March 2019-March 2021